Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
Identifieur interne : 000A86 ( Main/Exploration ); précédent : 000A85; suivant : 000A87Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
Auteurs : Sofia Avnet [Italie] ; Nicola Baldini [Italie] ; Lucie Brisson [France] ; Stine Falsig Pedersen [Danemark] ; Paolo E. Porporato [Italie] ; Pierre Sonveaux [Belgique] ; Gyorgy Szabadkai [Italie, Royaume-Uni] ; Silvia Pastorekova [Slovaquie]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17–20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.
Url:
DOI: 10.3389/fonc.2019.01332
PubMed: 31850217
PubMed Central: 6892776
Affiliations:
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These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17–20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Spugnini, Ep" uniqKey="Spugnini E">EP Spugnini</name></author><author><name sortKey="Sonveaux, P" uniqKey="Sonveaux P">P Sonveaux</name></author><author><name sortKey="Stock, C" uniqKey="Stock C">C Stock</name></author><author><name sortKey="Perez Sayans, M" uniqKey="Perez Sayans M">M Perez-Sayans</name></author><author><name sortKey="De Milito, A" uniqKey="De Milito A">A De Milito</name></author><author><name sortKey="Avnet, S" uniqKey="Avnet S">S Avnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldini, N" uniqKey="Baldini N">N Baldini</name></author><author><name sortKey="Sonveaux, P" uniqKey="Sonveaux P">P Sonveaux</name></author><author><name sortKey="De Milito, A" uniqKey="De Milito A">A De Milito</name></author><author><name sortKey="Supuran, C" uniqKey="Supuran C">C Supuran</name></author><author><name sortKey="Otto, A" uniqKey="Otto A">A Otto</name></author><author><name sortKey="Stock, C" uniqKey="Stock C">C Stock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldini, N" uniqKey="Baldini N">N Baldini</name></author><author><name sortKey="De Milito, A" uniqKey="De Milito A">A De Milito</name></author><author><name sortKey="Feron, O" uniqKey="Feron O">O Feron</name></author><author><name sortKey="Gillies, Rj" uniqKey="Gillies R">RJ Gillies</name></author><author><name sortKey="Michiels, C" uniqKey="Michiels C">C Michiels</name></author><author><name sortKey="Otto, Am" uniqKey="Otto A">AM Otto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avnet, S" uniqKey="Avnet S">S Avnet</name></author><author><name sortKey="Baldini, N" uniqKey="Baldini N">N Baldini</name></author><author><name sortKey="Brisson, L" uniqKey="Brisson L">L Brisson</name></author><author><name sortKey="De Milito, A" uniqKey="De Milito A">A De Milito</name></author><author><name sortKey="Otto, Am" uniqKey="Otto A">AM Otto</name></author><author><name sortKey="Pastorekova, S" uniqKey="Pastorekova S">S Pastorekova</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Slovaquie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Avnet, Sofia" sort="Avnet, Sofia" uniqKey="Avnet S" first="Sofia" last="Avnet">Sofia Avnet</name></noRegion><name sortKey="Baldini, Nicola" sort="Baldini, Nicola" uniqKey="Baldini N" first="Nicola" last="Baldini">Nicola Baldini</name><name sortKey="Baldini, Nicola" sort="Baldini, Nicola" uniqKey="Baldini N" first="Nicola" last="Baldini">Nicola Baldini</name><name sortKey="Porporato, Paolo E" sort="Porporato, Paolo E" uniqKey="Porporato P" first="Paolo E." last="Porporato">Paolo E. Porporato</name><name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name></country><country name="France"><noRegion><name sortKey="Brisson, Lucie" sort="Brisson, Lucie" uniqKey="Brisson L" first="Lucie" last="Brisson">Lucie Brisson</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Pedersen, Stine Falsig" sort="Pedersen, Stine Falsig" uniqKey="Pedersen S" first="Stine Falsig" last="Pedersen">Stine Falsig Pedersen</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Sonveaux, Pierre" sort="Sonveaux, Pierre" uniqKey="Sonveaux P" first="Pierre" last="Sonveaux">Pierre Sonveaux</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name></noRegion><name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name></country><country name="Slovaquie"><noRegion><name sortKey="Pastorekova, Silvia" sort="Pastorekova, Silvia" uniqKey="Pastorekova S" first="Silvia" last="Pastorekova">Silvia Pastorekova</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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